Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28941203 | 0.84 | HDAC8 (0.53) | ALDH1A1SMN1; SMN2HDAC8HDAC6HDAC1 | |
| SCHEMBL8801364 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HDAC8HDAC6HDAC1 | |
| SCHEMBL6086778 | 0.82 | HTR6 (0.66) | ALDH1A1SMN1; SMN2HDAC8HDAC6HDAC1 | |
| SCHEMBL30914586 | 0.82 | HTR6 (0.66) | ALDH1A1SMN1; SMN2HDAC8HDAC6HDAC1 | |
| SCHEMBL12472242 | 0.81 | HDAC8 (0.70) | ALDH1A1SMN1; SMN2HDAC8HDAC6HDAC1 | |
| SCHEMBL6086725 | 0.80 | HDAC8 (0.53) | ALDH1A1SMN1; SMN2HDAC8HDAC6HDAC1 | |
| Acrylamide SCHEMBL27983435 | 0.78 | PLAU (0.54) | ALDH1A1SMN1; SMN2HDAC8HDAC6HDAC1 | |
| SCHEMBL6087475 | 0.78 | HDAC8 (0.61) | ALDH1A1SMN1; SMN2HDAC8HDAC6HDAC1 | |
| SCHEMBL3496372 | 0.78 | HDAC8 (0.69) | ALDH1A1SMN1; SMN2HDAC8HDAC6HDAC1 | |
| SCHEMBL6190976 | 0.77 | HDAC8 (0.54) | HDAC8HDAC6HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1250542-C | 2-(1H-indol-3-yl)-2-oxo-acetamides with antitumor activity | NOVUSPHARMA SPA (IT) | 2006-04-12 | — | — | CN | disclosed |
| CN-1413205-A | 2- (1H-indol-3-yl) -2-oxo-acetamides with antitumor activity | NOVUSPHARMA SPA (IT) | 2003-04-23 | — | — | CN | disclosed |
| EP-1244652-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | Cell Therapeutics Europe S.R.L. (IT) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047916-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2001-07-05 | — | — | WO | disclosed |