Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 10/20 | 0.36 |
| ▸ | BCR | P11274 | 10/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | PLK4 | O00444 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27636379 | 0.87 | KDR (0.48) | KDRFGFR1FGFR2FGFR3ROCK1 | |
| SCHEMBL27636557 | 0.86 | FGFR2 (0.51) | KDRFGFR1FGFR2FGFR3NTRK2 | |
| SCHEMBL27636462 | 0.84 | KDR (0.60) | KDRFGFR1ROCK1NTRK2LTK | |
| SCHEMBL27636389 | 0.83 | KDR (0.49) | KDRFGFR1ROCK1NTRK2NTRK3 | |
| SCHEMBL27657396 | 0.81 | KDR (0.52) | KDRFGFR1FGFR2FGFR3ROCK1 | |
| SCHEMBL27636419 | 0.80 | KDR (0.52) | KDRFGFR1ROCK1NTRK2ABL1 | |
| SCHEMBL27657333 | 0.77 | KDR (0.54) | KDRFGFR1FGFR2FGFR3ROCK1 | |
| SCHEMBL27657358 | 0.76 | KDR (0.58) | KDRFGFR1ROCK1NTRK2LTK | |
| SCHEMBL27636383 | 0.76 | KDR (0.53) | KDRFGFR1ROCK1NTRK2LTK | |
| SCHEMBL27636373 | 0.75 | KDR (0.62) | KDRFGFR1ROCK1NTRK2LTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | claimed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-102417487-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB | 2012-04-18 | — | — | CN | disclosed |
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | disclosed |
| CN-101827584-A | Solid dispersion product of N-aryl ureido drugs | ABBOTT GMBH & CO KG | 2010-09-08 | — | — | CN | disclosed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | disclosed |