Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 7/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28338052 | 0.90 | KDM4E (0.55) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL6246810 | 0.88 | CTSC (0.54) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL10527592 | 0.88 | KMT2A (0.53) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL1533586 | 0.87 | KDM4E (0.68) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL20164946 | 0.87 | KDM4E (0.68) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL530950 | 0.87 | KDM4E (0.68) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28518234 | 0.87 | KDM4E (0.68) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28512622 | 0.87 | KDM4E (0.68) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28798150 | 0.87 | KDM4E (0.68) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL27622251 | 0.87 | KDM4E (0.68) | KDM4EMAPTMEN1LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105651923-B | The metabolic markers of unstable angina pectoris and acute myocardial infarction AMI are distinguished in diagnosis | 齐炼文 | 2017-10-27 | — | — | CN | claimed |
| CN-105651923-A | Metabolic marker for diagnosing and distinguishing unstable angina pectoris and acute myocardial infarction | 齐炼文 | 2016-06-08 | — | — | CN | claimed |
| CN-105651923-B | The metabolic markers of unstable angina pectoris and acute myocardial infarction AMI are distinguished in diagnosis | 齐炼文 | 2017-10-27 | — | — | CN | disclosed |
| CN-105651923-B | The metabolic markers of unstable angina pectoris and acute myocardial infarction AMI are distinguished in diagnosis | 齐炼文 | 2017-10-27 | — | — | CN | disclosed |
| CN-105651923-A | Metabolic marker for diagnosing and distinguishing unstable angina pectoris and acute myocardial infarction | 齐炼文 | 2016-06-08 | — | — | CN | disclosed |
| CN-105651923-A | Metabolic marker for diagnosing and distinguishing unstable angina pectoris and acute myocardial infarction | 齐炼文 | 2016-06-08 | — | — | CN | disclosed |
| CN-100497376-C | Antimicrobial polypeptides | NOVOZYMES AS (DK) | 2009-06-10 | — | — | CN | disclosed |
| CN-1820019-A | Antimicrobial polypeptides | NOVOZYMES AS (DK) | 2006-08-16 | — | — | CN | disclosed |