Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 3/20 | 0.46 |
| ▸ | MMP2 | P08253 | 3/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ECE1 | P42892 | 6/20 | 0.45 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL25306742 | 0.95 | KDM4E (0.50) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28130701 | 0.94 | KDM4E (0.63) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL27137424 | 0.92 | KDM4E (0.58) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL29176788 | 0.92 | KDM4E (0.58) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL2525328 | 0.91 | KDM4E (0.57) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL29078368 | 0.91 | NPBWR1 (0.50) | ERAP2KISS1R | |
| Dl-Tryptophan SCHEMBL10527592 | 0.91 | KMT2A (0.53) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL6246810 | 0.91 | CTSC (0.54) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL29151523 | 0.91 | KDM4E (0.54) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL27657501 | 0.90 | KDM4E (0.56) | KDM4EMAPTMEN1LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590915-A | Artificial antibacterial peptide CAH, preparation method and application thereof | 陕西科技大学 | 2019-12-20 | — | — | CN | disclosed |