Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990747 | 0.78 | MAPT (0.45) | KMT2AALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL22117014 | 0.76 | TSHR (0.36) | ALDH1A1MAPTSMN1; SMN2POLBHTT | |
| SCHEMBL27678434 | 0.75 | MET (0.43) | ALDH1A1MAPTPOLBLMNA | |
| SCHEMBL18498886 | 0.74 | MAOB (0.40) | KMT2AALDH1A1RECQLMAPTSMN1; SMN2 | |
| SCHEMBL12985694 | 0.73 | CYP3A4 (0.35) | KMT2AALDH1A1HTTHPGD | |
| SCHEMBL27732126 | 0.71 | KDM4E (0.40) | KMT2AALDH1A1RECQLMAPTRAB9A | |
| SCHEMBL22468486 | 0.70 | MAPT (0.40) | KMT2AALDH1A1RECQLMAPTNPC1 | |
| SCHEMBL20607733 | 0.69 | MAPT (0.39) | KMT2AALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL21591695 | 0.69 | MEN1 (0.37) | KMT2ASMN1; SMN2POLB | |
| SCHEMBL5344518 | 0.69 | ALDH1A1 (0.44) | KMT2AALDH1A1RECQLMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101933926-A | Indolylmaleimde derivatives as PKC inhibitors | NOVARTIS AG | 2011-01-05 | — | — | CN | disclosed |
| CN-1910173-B | Indolylmaleimide derivatives as PKC inhibitors | NOVARTIS AG | 2010-06-09 | — | — | CN | disclosed |
| CN-1910173-A | Indolylmaleimide derivatives as PKC inhibitors | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | disclosed |