Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | DPYD | Q12882 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23900415 | 0.76 | MAPK1 (0.56) | MAPK1DPYDKDM4EALDH1A1LMNA | |
| SCHEMBL11020641 | 0.73 | PDE3A (0.53) | MAPK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL3256572 | 0.72 | — | — | |
| SCHEMBL11629253 | 0.72 | PTGES (0.44) | MAPK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL11629097 | 0.72 | MAPK1 (0.47) | MAPK1DPYDKDM4EALDH1A1LMNA | |
| SCHEMBL14072055 | 0.72 | MAPK1 (0.47) | MAPK1DPYDXDHKDM4EHSD17B10 | |
| SCHEMBL2027355 | 0.72 | MAPK1 (0.69) | MAPK1DPYDKDM4EALDH1A1LMNA | |
| SCHEMBL12820646 | 0.72 | — | — | |
| SCHEMBL7513080 | 0.70 | — | — | |
| SCHEMBL27904495 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1835929-A | 6-arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors | BAYER HEALTHCARE AG (DE) | 2006-09-20 | — | — | CN | disclosed |