Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 7/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27694047 | 0.87 | IMPDH2 (0.42) | HTR1DHPGDCYP2C19MTNR1AMTNR1B | |
| SCHEMBL1465870 | 0.83 | HTR1D (0.44) | HTR1DHPGDCYP2C19MTNR1AMTNR1B | |
| SCHEMBL9268928 | 0.83 | HTR2A (0.53) | MTNR1AMTNR1BHTR2ATUBB4ATUBB | |
| SCHEMBL22166260 | 0.83 | HTR2C (0.53) | HTR1DHPGDCYP2C19MTNR1AMTNR1B | |
| SCHEMBL9854036 | 0.80 | MTNR1A (0.63) | HTR1DCYP2C19MTNR1AMTNR1BHTR1B | |
| SCHEMBL29611302 | 0.78 | HTR2A (0.47) | HTR1DCYP2C19HTR1BHTR2AHTR1A | |
| SCHEMBL273916 | 0.78 | HTR2A (0.47) | HTR1DCYP2C19HTR1BHTR2AHTR1A | |
| SCHEMBL4787969 | 0.77 | NQO2 (0.47) | — | |
| Hydrochloric Acid SCHEMBL30098563 | 0.77 | PMP22 (0.49) | HTR1DCYP2C19HTR1BHTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL4526379 | 0.77 | PMP22 (0.49) | HTR1DCYP2C19HTR1BHTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100441180-C | Use of sulfonamide derivatives as ligands for 5-ht6, in treatment of e.g. food ingestion disorder, obesity, bulimia, anorexia, cachexia and type ii diabetes | PARATEK PHARM INNC (ES) | 2008-12-10 | — | — | CN | disclosed |
| CN-1816334-A | Use of sulfonamide derivatives as ligands for 5-ht6, in treatment of e.g. food ingestion disorder, obesity, bulimia, anorexia, cachexia and type ii diabetes | PARATEK PHARM INNC (ES) | 2006-08-09 | — | — | CN | disclosed |