Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | BLM | P54132 | 2/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.63 |
| ▸ | MPO | P05164 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28131402 | 0.96 | KMT2A (0.58) | KMT2AKDM4EMAPTMEN1TSHR | |
| Dl-Tryptophan SCHEMBL28861116 | 0.96 | KMT2A (0.58) | KMT2AKDM4EMAPTMEN1TSHR | |
| Tryptophan SCHEMBL530950 | 0.96 | KDM4E (0.68) | KMT2AKDM4EMAPTMEN1TSHR | |
| Dl-Tryptophan SCHEMBL28518234 | 0.96 | KDM4E (0.68) | KMT2AKDM4EMAPTMEN1TSHR | |
| Dl-Tryptophan SCHEMBL27136864 | 0.96 | KDM4E (0.68) | KMT2AKDM4EMAPTMEN1TSHR | |
| Dl-Tryptophan SCHEMBL20164946 | 0.96 | KDM4E (0.68) | KMT2AKDM4EMAPTMEN1TSHR | |
| Dl-Tryptophan SCHEMBL1533586 | 0.96 | KDM4E (0.68) | KMT2AKDM4EMAPTMEN1TSHR | |
| Dl-Tryptophan SCHEMBL28512622 | 0.96 | KDM4E (0.68) | KMT2AKDM4EMAPTMEN1TSHR | |
| Dl-Tryptophan SCHEMBL28798150 | 0.96 | KDM4E (0.68) | KMT2AKDM4EMAPTMEN1TSHR | |
| Tryptophan SCHEMBL27622251 | 0.96 | KDM4E (0.68) | KMT2AKDM4EMAPTMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1889974-A | Oligopeptides as coating material for medical products | HEMOTEQ GMBH (DE) | 2007-01-03 | — | — | CN | claimed |
| CN-1889974-B | Oligopeptides as coating material for medical products | HEMOTEQ GMBH | 2012-08-29 | — | — | CN | disclosed |
| CN-100506841-C | Method and carrier complex for delivering molecules to cells | CORNELL RES FOUNDATION INC (US) | 2009-07-01 | — | — | CN | disclosed |
| CN-101440124-A | Methods for preventing mitochondrial permeability transition | CORNELL RES FOUNDATION INC (US) | 2009-05-27 | — | — | CN | disclosed |
| CN-1889974-A | Oligopeptides as coating material for medical products | HEMOTEQ GMBH (DE) | 2007-01-03 | — | — | CN | disclosed |