Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | MC4R | P32245 | 2/20 | 0.47 |
| ▸ | MC5R | P33032 | 1/20 | 0.47 |
| ▸ | MC3R | P41968 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28131402 | 1.00 | KMT2A (0.58) | KMT2AMEN1KDM4EMAPTTSHR | |
| Dl-Tryptophan SCHEMBL28250969 | 0.97 | KDM4E (0.54) | KMT2AMEN1KDM4EMAPTTSHR | |
| Dl-Tryptophan SCHEMBL27660745 | 0.96 | KMT2A (0.63) | KMT2AMEN1KDM4EMAPTTSHR | |
| Dl-Tryptophan SCHEMBL28130701 | 0.96 | KDM4E (0.63) | KMT2AMEN1KDM4EMAPTTSHR | |
| Tryptophan SCHEMBL27641188 | 0.94 | KDM4E (0.57) | KMT2AMEN1KDM4EMAPTTSHR | |
| Tryptophan SCHEMBL5064513 | 0.94 | KMT2A (0.57) | KMT2AMEN1KDM4EMAPTTSHR | |
| Dl-Tryptophan SCHEMBL27709285 | 0.94 | KDM4E (0.57) | KMT2AMEN1KDM4EMAPTTSHR | |
| Dl-Tryptophan SCHEMBL28366886 | 0.94 | KDM4E (0.57) | KMT2AMEN1KDM4EMAPTTSHR | |
| Dl-Tryptophan SCHEMBL29176788 | 0.93 | KDM4E (0.58) | KMT2AMEN1KDM4EMAPTTSHR | |
| Dl-Tryptophan SCHEMBL27137424 | 0.93 | KDM4E (0.58) | KMT2AMEN1KDM4EMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115028683-B | Pentapeptide compound and application thereof in preparation of medicines for treating liver fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-115028683-A | Pentapeptide compound and application thereof in preparation of medicine for treating hepatic fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2022-09-09 | — | — | CN | disclosed |