Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8510590 | 0.93 | L3MBTL1 (0.45) | NPC1UTS2RTLR8TLR7SMN1; SMN2 | |
| SCHEMBL8510998 | 0.89 | PDE5A (0.48) | NPC1KDM6BKDM4CPDE5AHTT | |
| SCHEMBL8670176 | 0.87 | HTT (0.50) | PDE5AHTTHSP90AA1HSP90AB1MAPT | |
| SCHEMBL31613110 | 0.87 | HTT (0.50) | PDE5AHTTHSP90AA1HSP90AB1MAPT | |
| SCHEMBL3968831 | 0.84 | PDE4B (0.43) | PDE5AHTTHSP90AA1HSP90AB1MAPT | |
| SCHEMBL8508286 | 0.81 | GRM5 (0.51) | HTTCYP3A4 | |
| SCHEMBL19897481 | 0.81 | BACE1 (0.54) | NPC1UTS2RTLR8TLR7KDM6B | |
| SCHEMBL1974279 | 0.81 | KDM4E (0.47) | NPC1UTS2RTLR8TLR7NR4A2 | |
| SCHEMBL30692781 | 0.81 | NPC1 (0.47) | NPC1UTS2RTLR8TLR7NR4A2 | |
| SCHEMBL7515463 | 0.80 | MAPT (0.44) | HTTMAPTKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1930144-A | 3-'4-heterocyclyl -1,2,3,-triazol-1-yl!-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases | BOEHRINGER INGELHEIM PHARMA (US) | 2007-03-14 | — | — | CN | disclosed |