Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 3/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | ARAF | P10398 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27516229 | 0.95 | CFTR (0.38) | POLBAPEX1KDRCFTRMAPT | |
| SCHEMBL27662009 | 0.85 | CFTR (0.36) | CFTRADRB2LMNA | |
| SCHEMBL27768015 | 0.83 | POLB (0.43) | POLBAPEX1LMNAGAAHTT | |
| SCHEMBL27543700 | 0.82 | CFTR (0.39) | CFTR | |
| SCHEMBL27641583 | 0.82 | CD44 (0.42) | POLBAPEX1MAPTGAAKMT2A | |
| SCHEMBL27767920 | 0.81 | POLB (0.43) | POLBAPEX1LMNAGAAHTT | |
| SCHEMBL27516903 | 0.79 | CFTR (0.36) | CFTRMAPTLMNAGAA | |
| SCHEMBL27539394 | 0.78 | GAA (0.35) | POLBAPEX1MAPTLMNAGAA | |
| SCHEMBL27539107 | 0.78 | LMNA (0.41) | POLBMAPTLMNAHTTMEN1 | |
| SCHEMBL5674056 | 0.75 | KDR (0.47) | KDRMAPTLMNAGAACDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1856312-A | Combination of mGluR2 antagonist and AChE inhibitor for treatment of acute and/or chronic neurological disorders | HOFFMANN LA ROCHE (CH) | 2006-11-01 | — | — | CN | disclosed |