Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | FADS1 | O60427 | 1/20 | 0.32 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27767920 | 0.94 | POLB (0.43) | POLBAPEX1HTTALPLGAA | |
| SCHEMBL27641583 | 0.84 | CD44 (0.42) | POLBAPEX1GAACA1CA2 | |
| SCHEMBL27662011 | 0.83 | POLB (0.35) | POLBAPEX1HTTGAALMNA | |
| SCHEMBL27516229 | 0.81 | CFTR (0.38) | POLBAPEX1HTTGAALMNA | |
| SCHEMBL27539394 | 0.81 | GAA (0.35) | POLBAPEX1HTTGAALMNA | |
| SCHEMBL27571037 | 0.78 | POLB (0.33) | POLBAPEX1HTTGAA | |
| SCHEMBL20521220 | 0.78 | FADS1 (0.37) | HTTALPLGAALMNAHTR2A | |
| SCHEMBL29286693 | 0.78 | POLB (0.36) | POLBAPEX1HTTKDM4E | |
| SCHEMBL27981649 | 0.77 | POLB (0.44) | POLBAPEX1HTTLMNAANO1 | |
| SCHEMBL27641592 | 0.77 | HDAC1 (0.38) | HTTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083799-B | Benzimidazole derivatives used as FXR agonists | HOFFMANN LA ROCHE | 2013-10-16 | — | — | CN | disclosed |
| CN-101855214-B | Benzimidazole derivatives and their use as FXR agonists | HOFFMANN LA ROCHE | 2012-12-26 | — | — | CN | disclosed |
| CN-101479249-B | Benzimidazole derivatives, method for the production thereof, their use as FXR agonists and pharmaceutical preparations containing them | HOFFMANN LA ROCHE | 2012-10-10 | — | — | CN | disclosed |
| CN-102083799-A | Benzimidazole derivatives used as FXR agonists | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101855214-A | Benzimidazole derivatives and their use as FXR agonists | HOFFMANN LA ROCHE | 2010-10-06 | — | — | CN | disclosed |
| CN-101479249-A | Benzimidazole derivatives, method for the production thereof, their use as FXR agonists and pharmaceutical preparations containing them | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |