Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27664470 | 0.87 | DRD2 (0.41) | DRD2HTR1ADRD3MEN1KMT2A | |
| SCHEMBL2783198 | 0.85 | HTR1A (0.46) | DRD2HTR1AHTR2AHTR7DRD3 | |
| SCHEMBL2780657 | 0.84 | DRD2 (0.48) | DRD2HTR1AHTR2AHTR7DRD3 | |
| SCHEMBL2783578 | 0.84 | DRD2 (0.46) | DRD2HTR1AHTR2ADRD3DRD4 | |
| SCHEMBL2783446 | 0.81 | DRD2 (0.43) | DRD2HTR1AHTR2AHTR7DRD3 | |
| SCHEMBL27664416 | 0.81 | DRD2 (0.42) | DRD2HTR1AHTR2AHTR7DRD3 | |
| SCHEMBL28761287 | 0.80 | DRD2 (0.44) | DRD2HTR1AHTR2AHTR7DRD3 | |
| SCHEMBL27684055 | 0.78 | DRD2 (0.50) | DRD2HTR1AHTR2ADRD3DRD4 | |
| SCHEMBL27684034 | 0.78 | SMN1; SMN2 (0.51) | DRD2HTR2ADRD3KMT2A | |
| SCHEMBL2783238 | 0.75 | DRD2 (0.56) | DRD2HTR1AHTR2AHTR7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1997630-A | New disubstituted phenylpiperidines as modulators of dopamine neurotransmission | NEUROSEARCH SWEDEN AB (SE) | 2007-07-11 | — | — | CN | claimed |
| CN-1997630-B | New disubstituted phenylpiperidines as modulators of dopamine neurotransmission | NEUROSEARCH SWEDEN AB | 2013-01-30 | — | — | CN | disclosed |
| CN-1997630-A | New disubstituted phenylpiperidines as modulators of dopamine neurotransmission | NEUROSEARCH SWEDEN AB (SE) | 2007-07-11 | — | — | CN | disclosed |