Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 3/20 | 0.45 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032604 | 0.97 | TRPC3 (0.42) | TRPC3TRPC6HPGDLMNAALDH1A1 | |
| SCHEMBL5032560 | 0.91 | HSD11B1 (0.49) | TRPC3TRPC6HPGDLMNAALDH1A1 | |
| SCHEMBL5034736 | 0.89 | HSD11B1 (0.45) | TRPC3TRPC6HPGDLMNAALDH1A1 | |
| SCHEMBL5032603 | 0.86 | LIPE (0.41) | TRPC3TRPC6HPGDLMNAALDH1A1 | |
| SCHEMBL5035129 | 0.85 | TRPC3 (0.40) | TRPC3TRPC6HPGDLMNAALDH1A1 | |
| SCHEMBL5032519 | 0.84 | DPP4 (0.42) | ALDH1A1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5032521 | 0.84 | DPP4 (0.42) | ALDH1A1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5034664 | 0.81 | KMT2A (0.47) | TRPC3TRPC6HPGDLMNAALDH1A1 | |
| SCHEMBL5034842 | 0.80 | HTR2C (0.46) | TRPC3TRPC6HPGDALDH1A1NPC1 | |
| SCHEMBL5035047 | 0.80 | HSD11B1 (0.40) | TRPC3TRPC6HPGDLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | claimed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | claimed |
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | disclosed |