Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.70 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL28509141 | 0.84 | NUDT1 (0.78) | AXLNUDT1KMT2ACDK8MAPK1 | |
| Formic Acid SCHEMBL30635274 | 0.84 | NUDT1 (0.78) | AXLNUDT1KMT2ACDK8MAPK1 | |
| SCHEMBL17837 | 0.84 | — | — | |
| SCHEMBL709685 | 0.84 | AXL (1.00) | AXLNUDT1CDK8DYRK1AMAPK1 | |
| SCHEMBL29523425 | 0.84 | — | — | |
| Potassium SCHEMBL30760557 | 0.82 | AXL (0.95) | AXLNUDT1CDK8DYRK1AMAPK1 | |
| Methane SCHEMBL14738986 | 0.82 | AXL (0.95) | AXLNUDT1CDK8DYRK1AMAPK1 | |
| Hydrochloric Acid SCHEMBL27893779 | 0.82 | AXL (0.95) | AXLNUDT1CDK8DYRK1AMAPK1 | |
| Bromide SCHEMBL27394282 | 0.82 | AXL (0.95) | AXLNUDT1CDK8DYRK1AMAPK1 | |
| SCHEMBL27753650 | 0.82 | AXL (0.95) | AXLNUDT1CDK8DYRK1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1950083-A | Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors | AVENTIS PHARMA SA (FR) | 2007-04-18 | — | — | CN | disclosed |