Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 4/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27838499 | 0.92 | KDM1A (0.48) | KDM1AKCNH2MAOBTNKS2CYP4F2 | |
| SCHEMBL6583019 | 0.87 | MAOB (0.56) | KDM1AKCNH2MAOBTNKS2CYP4F2 | |
| SCHEMBL23364801 | 0.82 | KCNH2 (0.49) | KDM1AKCNH2MAOBTNKS2CYP4F2 | |
| SCHEMBL23380025 | 0.82 | KDM1A (0.48) | KDM1AKCNH2MAOBTNKS2CYP4F2 | |
| SCHEMBL6583023 | 0.81 | SPHK1 (0.58) | KDM1AKCNH2MAOBTNKS2CYP4F2 | |
| SCHEMBL6588487 | 0.81 | SPHK1 (0.55) | KDM1AKCNH2MAOBTNKS2CYP4F2 | |
| SCHEMBL29666652 | 0.81 | KCNH2 (0.53) | KDM1AKCNH2MAOBTNKS2CYP4F2 | |
| SCHEMBL23364637 | 0.81 | AKR1C3 (0.58) | KDM1AKCNH2MAOBTNKS2CYP4F2 | |
| SCHEMBL12354455 | 0.80 | SPHK1 (0.60) | KDM1AKCNH2MAOBTNKS2CYP4F2 | |
| SCHEMBL32665130 | 0.79 | KDM1A (0.53) | KDM1AKCNH2MAOBTNKS2CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1898240-B | Imidazopyrazine tyrosine kinase inhibitors | OSI PHARM INC | 2011-08-03 | — | — | CN | claimed |
| CN-1898240-A | Imidazopyrazine tyrosine kinase inhibitors | OSI PHARM INC (US) | 2007-01-17 | — | — | CN | claimed |