Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12354455 | 0.98 | SPHK1 (0.60) | SPHK1KCNH2MAOBKDM1ATNKS2 | |
| SCHEMBL6588487 | 0.97 | SPHK1 (0.55) | SPHK1KCNH2MAOBKDM1ATNKS2 | |
| SCHEMBL6583019 | 0.94 | MAOB (0.56) | SPHK1KCNH2MAOBKDM1ATNKS2 | |
| SCHEMBL29666652 | 0.87 | KCNH2 (0.53) | SPHK1KCNH2MAOBKDM1ATNKS2 | |
| SCHEMBL12735838 | 0.87 | HTR2C (0.60) | SPHK1KCNH2MAOBKDM1ATNKS2 | |
| SCHEMBL27649525 | 0.86 | KCNH2 (0.47) | SPHK1KCNH2MAOBKDM1ATNKS2 | |
| SCHEMBL27838499 | 0.85 | KDM1A (0.48) | SPHK1KCNH2MAOBKDM1ATNKS2 | |
| SCHEMBL11638505 | 0.84 | KCNH2 (0.51) | KCNH2MAOBKDM1ATNKS2 | |
| SCHEMBL9419127 | 0.84 | GRIN1 (0.48) | SPHK1KCNH2MAOBKDM1ATNKS2 | |
| SCHEMBL28190298 | 0.83 | TNKS2 (0.52) | KCNH2MAOBKDM1ATNKS2CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1523015-A | 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines | �Ʒ� | 2004-08-25 | — | — | CN | disclosed |
| CN-1515554-A | Intermediate compound for producing 2-amino-6-(2-substituted-4-phenoxy) substituted pyridine compound | �Ʒ� | 2004-07-28 | — | — | CN | disclosed |
| EP-0958282-B1 | 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES | PFIZER PROD INC (US) | 2004-07-21 | — | — | EP | disclosed |
| US-20030162765-A1 | Use in treatment and prevention of central nervous system and other disorders | PFIZER INC. | 2003-08-28 | — | — | US | disclosed |
| US-20010007873-A1 | Compounds such as 4-(6-amino-pyridin-2-yl)-3-methoxyphenol as nitric oxide synthase inhibitors used to treat central nervous system disorders, inflammatory disorders, septic shock, etc... | PFIZER INC. | 2001-07-12 | — | — | US | disclosed |
| CN-1246848-A | 2-amino-6- (2-substituted-4-phenoxy) -substituted pyridines | PFIZER PROD INC (US) | 2000-03-08 | — | — | CN | disclosed |
| EP-0958282-A1 | 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES | Pfizer Products Inc. (US) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998034919-A1 | 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES | PFIZER PRODUCTS INC. (US) | 1998-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010007873-A1 | Compounds such as 4-(6-amino-pyridin-2-yl)-3-methoxyphenol as nitric oxide synthase inhibitors used to treat central nervous system disorders, inflammatory disorders, septic shock, etc... | NOS1, PTGS1, NOS2 | SPHK1 1670/4885KCNH2 2408/4885MAOB 255/4885 |
| US-20030162765-A1 | Use in treatment and prevention of central nervous system and other disorders | GRIN2C, GRIN2A, CNR2 | SPHK1 2078/4885KCNH2 1308/4885MAOB 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.