Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PSMD10 | O75832 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187914 | 0.93 | CA1 (0.47) | STAT3ALDH1A1TSHRCYP2C9LMNA | |
| SCHEMBL8927880 | 0.93 | CA1 (0.47) | STAT3ALDH1A1TSHRCYP2C9LMNA | |
| SCHEMBL359236 | 0.92 | CA1 (0.46) | STAT3ALDH1A1TSHRCYP2C9LMNA | |
| Ammonia Solution, Strong SCHEMBL7973010 | 0.92 | CA1 (0.46) | STAT3ALDH1A1TSHRCYP2C9LMNA | |
| SCHEMBL283871 | 0.88 | MCHR1 (0.47) | ALDH1A1TSHRCYP2C9CA12CA1 | |
| SCHEMBL14476452 | 0.87 | ALDH1A1 (0.45) | ALDH1A1TSHRCYP2C9LMNAALB | |
| SCHEMBL2414757 | 0.87 | ALDH1A1 (0.45) | STAT3ALDH1A1TSHRCYP2C9LMNA | |
| SCHEMBL10725263 | 0.87 | RECQL (0.50) | ALDH1A1TSHRCYP2C9CA12CA1 | |
| SCHEMBL2194649 | 0.87 | RECQL (0.50) | ALDH1A1TSHRCYP2C9CA12CA1 | |
| SCHEMBL3088278 | 0.87 | RECQL (0.50) | ALDH1A1TSHRCYP2C9CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100374480-C | Process for producing aromatic polycarbonate | MITSUBISHI CHEM CORP (JP) | 2008-03-12 | — | — | CN | disclosed |
| CN-1839170-A | Process for producing aromatic polycarbonate | MITSUBISHI CHEM CORP (JP) | 2006-09-27 | — | — | CN | disclosed |