Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.43 |
| ▸ | GRM8 | O00222 | 2/20 | 0.43 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27670939 | 0.90 | CRHR1 (0.52) | CYP1A2GRM8GRM7CYP2C9TACR1 | |
| SCHEMBL7438135 | 0.76 | CRHR1 (0.44) | CYP1A2GRM8GRM7CYP2C9TACR1 | |
| SCHEMBL5600230 | 0.72 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL7438143 | 0.68 | CRHR1 (0.42) | MEN1KMT2ACRHR1LMNAMAPT | |
| SCHEMBL5600227 | 0.68 | CRHR1 (0.73) | CRHR1 | |
| SCHEMBL5600236 | 0.67 | CRHR1 (0.42) | CRHR1LMNANPY1R | |
| SCHEMBL5599612 | 0.67 | CRHR1 (0.80) | CRHR1 | |
| SCHEMBL7441810 | 0.67 | CRHR1 (0.52) | MEN1KMT2ACRHR1HTTMAPT | |
| SCHEMBL7434748 | 0.67 | CRHR1 (0.48) | CRHR1NPY1R | |
| SCHEMBL13134057 | 0.65 | CRHR1 (0.70) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1917882-A | Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists | PFIZER (US) | 2007-02-21 | — | — | CN | claimed |
| CN-1917882-A | Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists | PFIZER (US) | 2007-02-21 | — | — | CN | disclosed |