Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 9/20 | 0.55 |
| ▸ | MMP2 | P08253 | 9/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.55 |
| ▸ | MMP9 | P14780 | 6/20 | 0.55 |
| ▸ | CTSB | P07858 | 3/20 | 0.50 |
| ▸ | CTSS | P25774 | 3/20 | 0.50 |
| ▸ | CTSK | P43235 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174637 | 1.00 | ADAM10 (0.55) | ADAM10MMP2ERBB2MMP9CTSB | |
| SCHEMBL2173705 | 1.00 | ADAM10 (0.55) | ADAM10MMP2ERBB2MMP9CTSB | |
| SCHEMBL3458222 | 0.88 | ADAM10 (0.57) | ADAM10MMP2ERBB2MMP9CTSB | |
| SCHEMBL3457848 | 0.88 | ADAM10 (0.57) | ADAM10MMP2ERBB2MMP9CTSB | |
| Trifluoroacetic Acid SCHEMBL2177021 | 0.81 | ADAM10 (0.67) | ADAM10MMP2ERBB2MMP9CTSB | |
| SCHEMBL2173414 | 0.81 | ADAM10 (0.53) | ADAM10MMP2ERBB2MMP9CTSB | |
| SCHEMBL2172824 | 0.78 | ADAM10 (0.57) | ADAM10MMP2ERBB2MMP9CTSB | |
| SCHEMBL2173711 | 0.78 | ADAM10 (0.57) | ADAM10MMP2ERBB2MMP9CTSB | |
| SCHEMBL27671953 | 0.78 | ADAM10 (0.57) | ADAM10MMP2ERBB2MMP9CTSB | |
| SCHEMBL2173170 | 0.76 | ADAM10 (0.54) | ADAM10MMP2ERBB2MMP9CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1898234-A | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | INCYTE CORP (US) | 2007-01-17 | — | — | CN | disclosed |