Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 9/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.57 |
| ▸ | MMP2 | P08253 | 9/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | CTSB | P07858 | 2/20 | 0.53 |
| ▸ | CTSS | P25774 | 2/20 | 0.53 |
| ▸ | CTSK | P43235 | 2/20 | 0.53 |
| ▸ | MMP9 | P14780 | 5/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27671953 | 1.00 | ADAM10 (0.57) | ADAM10ERBB2MMP2SIGMAR1CTSB | |
| SCHEMBL2173711 | 1.00 | ADAM10 (0.57) | ADAM10ERBB2MMP2SIGMAR1CTSB | |
| SCHEMBL3456417 | 0.87 | SIGMAR1 (0.60) | ADAM10ERBB2MMP2SIGMAR1CTSB | |
| SCHEMBL3457734 | 0.87 | SIGMAR1 (0.60) | ADAM10ERBB2MMP2SIGMAR1CTSB | |
| SCHEMBL2172763 | 0.85 | ADAM10 (0.75) | ADAM10ERBB2MMP2SIGMAR1CTSB | |
| SCHEMBL2172052 | 0.83 | ADAM10 (0.53) | ADAM10ERBB2MMP2SIGMAR1CTSB | |
| SCHEMBL27671958 | 0.82 | ADAM10 (0.54) | ADAM10ERBB2MMP2SIGMAR1CTSB | |
| SCHEMBL2173170 | 0.82 | ADAM10 (0.54) | ADAM10ERBB2MMP2SIGMAR1CTSB | |
| SCHEMBL2173561 | 0.81 | ADAM10 (0.62) | ADAM10ERBB2MMP2SIGMAR1MMP9 | |
| SCHEMBL2173173 | 0.81 | ADAM10 (0.62) | ADAM10ERBB2MMP2SIGMAR1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440958-B2 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | INCYTE CORPORATION (US) | 2016-09-13 | — | — | US | disclosed |
| US-20110224189-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION | 2011-09-15 | — | — | US | disclosed |
| US-7973041-B2 | Antiarthritic agents; psoriasis; anticancer agents;antiallergens; metalloprotease inhibitors. | INCYTE CORPORATION (US) | 2011-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224189-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | MMP25, MMP14, MMP9 | ADAM10 25/4885ERBB2 2986/4885MMP2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.