Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2795484 | 0.85 | KCNMA1 (0.65) | NPC1KCNMA1KDM4EMEN1KMT2A | |
| SCHEMBL4799616 | 0.82 | NPC1 (0.61) | NPC1ALDH1A1KDM4EGAARAB9A | |
| SCHEMBL30274478 | 0.82 | NPC1 (0.61) | NPC1ALDH1A1KDM4EGAARAB9A | |
| SCHEMBL1851955 | 0.82 | CXCR2 (0.57) | CXCR2NPC1ERBB2HSP90AA1HSP90AB1 | |
| SCHEMBL1952367 | 0.81 | POLB (0.67) | CXCR2NPC1ERBB2HSP90AA1HSP90AB1 | |
| SCHEMBL7535590 | 0.80 | CXCR1 (0.57) | CXCR2NPC1ALDH1A1KDM4EGAA | |
| SCHEMBL20227392 | 0.80 | NPC1 (0.66) | CXCR2NPC1KDM4EGAARAB9A | |
| SCHEMBL6220830 | 0.79 | MAPK1 (0.59) | NPC1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL13283740 | 0.79 | NPC1 (0.50) | NPC1KCNMA1ALDH1A1KDM4EGLA | |
| SCHEMBL10522333 | 0.79 | NPC1 (0.50) | CXCR2NPC1ALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101875961-A | Be used to prevent and treat associated conditions and as the diaryl and the aryl heteroaryl urea derivatives of 5-HT2A serotonin receptor modulator | ARENA PHARM INC | 2010-11-03 | — | — | CN | disclosed |
| CN-101871931-A | Be used to prevent and treat associated conditions and as the diaryl and the aryl heteroaryl urea derivatives of 5-HT2A serotonin receptor modulator | ARENA PHARM INC | 2010-10-27 | — | — | CN | disclosed |
| CN-1826322-A | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT 2A serotonin receptor for the prevention and treatment of related disorders | ARENA PHARM INC (US) | 2006-08-30 | — | — | CN | disclosed |