Sugi Predict

Sugi Predict / Compounds / SCHEMBL2795484

SCHEMBL2795484

SCHEMBL2795484

NC(=O)Nc1cc(Cl)ccc1O

nearest known ligand 0.65

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ KCNMA1 Q12791 14/20 0.65
▸ POLB P06746 1/20 0.64
▸ ALOX15 P16050 1/20 0.56
▸ MAPK1 P28482 1/20 0.56
▸ KDM4E B2RXH2 1/20 0.54
▸ HIF1A Q16665 1/20 0.54
▸ MEN1 O00255 1/20 0.53
▸ HPGD P15428 1/20 0.53
▸ KMT2A Q03164 1/20 0.53
▸ STAT3 P40763 1/20 0.52
▸ NPC1 O15118 1/20 0.52
▸ CHRNA7 P36544 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27672011 0.85 CXCR2 (0.59) KCNMA1POLBKDM4EMEN1KMT2A
SCHEMBL28295632 0.84 KCNMA1 (0.68) KCNMA1POLBALOX15MAPK1MEN1
SCHEMBL9170975 0.82 POLB (0.71) KCNMA1POLBALOX15MAPK1MEN1
SCHEMBL5150505 0.82 MEN1 (0.67) POLBMEN1KMT2ANPC1
SCHEMBL1249700 0.81 KCNMA1 (0.64) KCNMA1POLBKDM4EHIF1AMEN1
SCHEMBL5144511 0.81 POLB (0.86) KCNMA1POLBALOX15MAPK1MEN1
SCHEMBL8355642 0.81 NPC1 (0.52) KCNMA1POLBKDM4EMEN1KMT2A
SCHEMBL19575701 0.81 NPC1 (0.52) KCNMA1POLBALOX15KDM4EMEN1
SCHEMBL7114040 0.81 KCNMA1 (0.54) KCNMA1POLBALOX15MAPK1MEN1
SCHEMBL27775431 0.81 GRIK1 (0.53) KCNMA1POLBMEN1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100546977-C Suppress the new compound and the application thereof of rotamase JERINI AG (DE) 2009-10-07 — — CN claimed
US-6635091-B2 Oxidation color dye and coupler L'OREAL S. A. (FR) 2003-10-21 — — US claimed
US-20020178512-A1 Oxidation dyeing composition for keratinous fibres comprising a n-(2-hydrobenzene)-carbamate or a n-(2-hydroxy-benzene)-urea and a pyrazolopyrimine, dyeing methods L'OREAL SA (FR) 2002-12-05 — — US claimed
EP-1175198-A1 OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES COMPRISING A N-(2-HYDROBENZENE)-CARBAMATE OR A N-(2-HYDROXY-BENZENE)-UREA AND A PYRAZOLOPYRIMINE, DYEING METHODS L'OREAL (FR) 2002-01-30 — — EP claimed
US-20010034914-A1 Compositions for the oxidation dyeing of keratinous fibers comprising at least one coupler, and dyeing methods L'OREAL S.A. (FR) 2001-11-01 — — US claimed
EP-1129689-A2 Keratinous fiber dyeing composition comprising N-(2-hydroxybenzene)-carbamate or N-(2-hydroxybenzene)urea derivatives as coupling agents and process for dyeing L'OREAL (FR) 2001-09-05 — — EP claimed
WO-2001062220-A1 OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES COMPRISING A N-(2-HYDROBENZENE)-CARBAMATE OR A N-(2-HYDROXY-BENZENE)-UREA AND A PYRAZOLOPYRIMINE, DYEING METHODS L'OREAL (FR) 2001-08-30 — — WO claimed
WO-1999029640-A2 COMPOSITIONS AND METHODS FOR MODULATING THE ACTIVITY OF FIBROBLAST GROWTH FACTOR EISAI CO., LTD. (JP) 1999-06-17 — — WO claimed
US-9567308-B1 Process for the synthesis of chlorzoxazone PROCOS S.P.A. (IT) 2017-02-14 — — US disclosed
US-20170022172-A1 PROCESS FOR THE SYNTHESIS OF CHLORZOXAZONE PROCOS S.P.A. (IT) 2017-01-26 — — US disclosed
EP-3021856-A1 A METHOD FOR ORGAN ARREST, PROTECTION AND PRESERVATION AND REDUCING TISSUE INJURY Hibernation Therapeutics, a KF LLC (US) 2016-05-25 — — EP disclosed
EP-3021855-A1 A METHOD FOR TREATING HAEMORRHAGE, SHOCK AND BRAIN INJURY Hibernation Therapeutics, a KF LLC (US) 2016-05-25 — — EP disclosed
WO-2015188060-A1 FLUOROSULFONYL sEH INHIBITORS THE SCRIPPS RESEARCH INSTITUTE (US) 2015-12-10 — — WO disclosed
WO-2015006828-A1 A METHOD FOR TREATING HAEMORRHAGE, SHOCK AND BRAIN INJURY HTS THERAPEUTICS PTY LTD (AU) 2015-01-22 — — WO disclosed
EP-1129689-A2 Keratinous fiber dyeing composition comprising N-(2-hydroxybenzene)-carbamate or N-(2-hydroxybenzene)urea derivatives as coupling agents and process for dyeing L'OREAL (FR) 2001-09-05 — — EP disclosed
WO-2001062757-A1 NOVEL COMPOUNDS ASTRAZENECA AB (SE) 2001-08-30 — — WO disclosed
WO-2001062220-A1 OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES COMPRISING A N-(2-HYDROBENZENE)-CARBAMATE OR A N-(2-HYDROXY-BENZENE)-UREA AND A PYRAZOLOPYRIMINE, DYEING METHODS L'OREAL (FR) 2001-08-30 — — WO disclosed
WO-2001062728-A1 NOVEL COMPOUNDS ASTRAZENECA AB (SE) 2001-08-30 — — WO disclosed
WO-2001062729-A1 NOVEL COMPOUNDS ASTRAZENECA AB (SE) 2001-08-30 — — WO disclosed
WO-1999029640-A2 COMPOSITIONS AND METHODS FOR MODULATING THE ACTIVITY OF FIBROBLAST GROWTH FACTOR EISAI CO., LTD. (JP) 1999-06-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010034914-A1 Compositions for the oxidation dyeing of keratinous fibers comprising at least one coupler, and dyeing methods KRT18, FH, FGB KCNMA1 928/4885POLB 60/4885ALOX15 1961/4885
US-20020178512-A1 Oxidation dyeing composition for keratinous fibres comprising a n-(2-hydrobenzene)-carbamate or a n-(2-hydroxy-benzene)-urea and a pyrazolopyrimine, dyeing methods FH, KRT18, CYB5R3 KCNMA1 1647/4885POLB 123/4885ALOX15 2480/4885
US-20170022172-A1 PROCESS FOR THE SYNTHESIS OF CHLORZOXAZONE CPS1, PPP2CA, PAOX KCNMA1 3195/4885POLB 190/4885ALOX15 1992/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.