Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CTSV | O60911 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | PPIA | P62937 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27651789 | 0.92 | CYP19A1 (0.43) | MEN1KMT2AMAPTCYP19A1PTGDR2 | |
| SCHEMBL27793517 | 0.88 | PTGDR2 (0.42) | MEN1KMT2AMAPTPTGDR2ALDH1A1 | |
| SCHEMBL27814942 | 0.85 | ALDH1A1 (0.43) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL27651730 | 0.82 | CYP19A1 (0.37) | MEN1KMT2AMAPTCYP19A1PTGDR2 | |
| SCHEMBL27997806 | 0.81 | MRGPRX4 (0.40) | L3MBTL1 | |
| SCHEMBL27651757 | 0.80 | MEN1 (0.47) | MEN1KMT2AMAPTCYP19A1PTGDR2 | |
| SCHEMBL28856733 | 0.77 | KMT2A (0.39) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL28035339 | 0.74 | NR4A2 (0.46) | SMN1; SMN2 | |
| SCHEMBL27519436 | 0.73 | NR4A2 (0.39) | MEN1KMT2AALDH1A1 | |
| SCHEMBL2874685 | 0.72 | PTGDR2 (0.69) | MEN1KMT2AMAPTCYP19A1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101875961-B | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related therto | ARENA PHARM INC | 2015-01-07 | — | — | CN | disclosed |
| CN-1826322-B | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor for the prevention and treatment of related disorders | ARENA PHARM INC | 2012-04-18 | — | — | CN | disclosed |
| CN-101875961-A | Be used to prevent and treat associated conditions and as the diaryl and the aryl heteroaryl urea derivatives of 5-HT2A serotonin receptor modulator | ARENA PHARM INC | 2010-11-03 | — | — | CN | disclosed |
| CN-101871931-A | Be used to prevent and treat associated conditions and as the diaryl and the aryl heteroaryl urea derivatives of 5-HT2A serotonin receptor modulator | ARENA PHARM INC | 2010-10-27 | — | — | CN | disclosed |
| CN-1826322-A | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT 2A serotonin receptor for the prevention and treatment of related disorders | ARENA PHARM INC (US) | 2006-08-30 | — | — | CN | disclosed |