Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 8/20 | 0.45 |
| ▸ | MMP13 | P45452 | 7/20 | 0.45 |
| ▸ | MMP1 | P03956 | 5/20 | 0.45 |
| ▸ | MMP7 | P09237 | 2/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.42 |
| ▸ | MMP2 | P08253 | 6/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140971 | 0.84 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| SCHEMBL27529782 | 0.84 | SLC6A4 (0.53) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| SCHEMBL9396845 | 0.84 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL20140710 | 0.83 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| SCHEMBL20140984 | 0.82 | SLC6A4 (0.50) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| SCHEMBL21360355 | 0.82 | SLC6A4 (0.50) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| SCHEMBL4238187 | 0.82 | SLC6A4 (0.50) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| SCHEMBL29178290 | 0.81 | KAT6A (0.43) | SLC6A2SLC6A4SLC6A3MMP9MMP13 | |
| SCHEMBL21360310 | 0.81 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3MMP9MMP13 | |
| SCHEMBL16731889 | 0.81 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1898234-A | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | INCYTE CORP (US) | 2007-01-17 | — | — | CN | disclosed |