Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27651812 | 0.89 | FKBP1A (0.46) | FKBP1ACYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL27672028 | 0.78 | PKM (0.43) | MEN1KMT2ASMN1; SMN2CTSS | |
| SCHEMBL27672077 | 0.77 | HTT (0.49) | CYP2C9CYP2C19MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17117357 | 0.76 | NAMPT (0.66) | FKBP1ACYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL17117403 | 0.75 | NAMPT (0.67) | FKBP1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9833782 | 0.73 | FKBP1A (0.58) | FKBP1ACYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL28218804 | 0.72 | MEN1 (0.74) | FKBP1ACYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL7068444 | 0.71 | FKBP1A (0.82) | FKBP1ACYP2C19SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL1953978 | 0.70 | FKBP1A (0.80) | FKBP1ASMN1; SMN2POLBSIGMAR1MAPT | |
| SCHEMBL8393626 | 0.69 | USP2 (0.64) | FKBP1ACYP2C9CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100543017-C | Keto-oxadiazole derivatives as cathepsin inhibitors | AVENTIS PHARMA INC (US) | 2009-09-23 | — | — | CN | disclosed |
| CN-1898219-A | Novel keto-oxadiazole derivatives as cathepsin inhibitors | AVENTIS PHARMA INC (US) | 2007-01-17 | — | — | CN | disclosed |