Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.51 |
| ▸ | BMP4 | P12644 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35327 | 0.94 | TGFBR1 (0.60) | TGFBR1MAPK14PIK3CAGRM4HTR2B | |
| SCHEMBL30439957 | 0.94 | TGFBR1 (0.60) | TGFBR1MAPK14PIK3CAGRM4HTR2B | |
| SCHEMBL12074333 | 0.90 | PIK3CA (0.65) | TGFBR1MAPK14PIK3CAGRM4HTR2B | |
| SCHEMBL12580413 | 0.84 | PIK3CA (0.54) | TGFBR1MAPK14PIK3CAGRM4HTR2B | |
| SCHEMBL12580359 | 0.84 | PIK3CA (0.54) | TGFBR1MAPK14PIK3CAGRM4HTR2B | |
| SCHEMBL27898092 | 0.82 | PIK3CA (0.65) | TGFBR1MAPK14PIK3CAGRM4HTR2B | |
| SCHEMBL4658401 | 0.82 | CA12 (0.59) | TGFBR1MAPK14PIK3CAGRM4HTR2B | |
| SCHEMBL21131938 | 0.82 | PIK3CA (0.53) | TGFBR1MAPK14PIK3CAGRM4HTR2B | |
| SCHEMBL12580372 | 0.82 | PIK3CA (0.56) | TGFBR1MAPK14PIK3CAGRM4HTR2B | |
| SCHEMBL12580422 | 0.82 | PIK3CA (0.56) | TGFBR1MAPK14PIK3CAGRM4HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100567291-C | Diastereoselective synthesis method using 6-bromo-4- (3-chlorophenyl) -2-methoxyquinoline | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-09 | — | — | CN | disclosed |
| CN-1946710-A | Diastereoselective synthesis process with 6-bromo-4-(3-chlorophenyl)-2-methoxy-quinoline | JANSSEN PHARMACEUTICA NV (BE) | 2007-04-11 | — | — | CN | disclosed |