Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237591 | 0.86 | TBXAS1 (0.59) | TBXAS1PTGS1PTGS2LMNACYP2C9 | |
| SCHEMBL27700760 | 0.85 | TSHR (0.49) | TSHRTDP1HPGD | |
| SCHEMBL28031596 | 0.85 | TBXAS1 (0.51) | TBXAS1PTGS1PTGS2LMNACYP2C9 | |
| SCHEMBL19553549 | 0.83 | PPARG (0.51) | TBXAS1PTGS1PTGS2LMNACYP2C9 | |
| SCHEMBL27731677 | 0.83 | PLA2G10 (0.45) | TBXAS1PTGS2TDP1FFAR1HPGD | |
| SCHEMBL11471957 | 0.81 | TBXAS1 (0.49) | TBXAS1PTGS1PTGS2LMNACYP2C9 | |
| SCHEMBL21129085 | 0.81 | MEN1 (0.57) | TBXAS1PTGS1PTGS2LMNACYP2C9 | |
| SCHEMBL4597385 | 0.81 | MEN1 (0.57) | TBXAS1PTGS1PTGS2LMNACYP2C9 | |
| SCHEMBL12939732 | 0.81 | MEN1 (0.57) | TBXAS1PTGS1PTGS2LMNACYP2C9 | |
| SCHEMBL28022217 | 0.81 | ESR1 (0.44) | PTGS2CYP2C9CXCR1CXCR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101374841-A | Spiroimidazole Derivatives as PPAR Modulators | IRM LLC (BM) | 2009-02-25 | — | — | CN | disclosed |
| CN-1914173-A | Quinolines useful in treating cardiovascular disease | WYETH CORP (US) | 2007-02-14 | — | — | CN | disclosed |