Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27674018 | 0.85 | TBXAS1 (0.49) | TSHRTDP1HPGD | |
| SCHEMBL28204052 | 0.84 | TSHR (0.44) | TSHRTDP1KMT2AMEN1 | |
| SCHEMBL16080190 | 0.83 | OPRK1 (0.50) | TSHRCYP1A2KMT2AMEN1HTT | |
| SCHEMBL17590311 | 0.83 | TSHR (0.50) | TSHRTDP1GABRR1CYP1A2HPGD | |
| SCHEMBL27500484 | 0.83 | OPRK1 (0.50) | TSHRCYP1A2KMT2AMEN1HTT | |
| SCHEMBL25181550 | 0.83 | TSHR (0.50) | TSHRTDP1GABRR1CYP1A2HPGD | |
| SCHEMBL264775 | 0.82 | TSHR (0.68) | TSHRKMT2AMEN1HPGDHTT | |
| SCHEMBL12670558 | 0.82 | TSHR (0.68) | TSHRKMT2AMEN1HPGDHTT | |
| SCHEMBL1073143 | 0.82 | TSHR (0.68) | TSHRKMT2AMEN1HPGDHTT | |
| SCHEMBL473576 | 0.82 | TSHR (0.68) | TSHRKMT2AMEN1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101035765-B | Sulfonamide derivatives | HOFFMANN LA ROCHE | 2010-10-13 | — | — | CN | disclosed |
| CN-101747324-A | Sulfonamide derivatives | HOFFMANN LA ROCHE | 2010-06-23 | — | — | CN | disclosed |
| CN-101035765-A | Sulfonamide derivatives | HOFFMANN LA ROCHE (CH) | 2007-09-12 | — | — | CN | disclosed |