Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908930 | 0.89 | ABCB1 (0.44) | TDP1ALDH1A1HSD17B10LMNAHTT | |
| SCHEMBL27655242 | 0.86 | TDP1 (0.44) | TDP1ALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL16160281 | 0.81 | KMT2A (0.49) | TDP1ALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL26926495 | 0.80 | AKR1C3 (0.51) | TDP1LMNAHTTRAB9ANPC1 | |
| SCHEMBL27858128 | 0.75 | PPARA (0.60) | TDP1ALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL2908569 | 0.74 | NPC1 (0.43) | TDP1LMNAHTTEGFRSMN1; SMN2 | |
| SCHEMBL224130 | 0.72 | ALDH1A1 (0.75) | TDP1ALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL3451893 | 0.69 | L3MBTL1 (0.57) | ALDH1A1HSD17B10HTTEGFRRAB9A | |
| SCHEMBL27960517 | 0.68 | HIF1A (0.52) | TDP1ALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL5065687 | 0.68 | TDP1 (0.68) | TDP1ALDH1A1HSD17B10TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1922144-A | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs | MEMORY PHARM CORP (US) | 2007-02-28 | — | — | CN | disclosed |