Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693559 | 0.88 | KDM4E (0.51) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL27693542 | 0.87 | CNR2 (0.45) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL27675144 | 0.87 | MAPT (0.43) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL27693495 | 0.84 | LMNA (0.49) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL28768803 | 0.84 | CNR2 (0.51) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL27675205 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL27693503 | 0.82 | CFTR (0.47) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL27693487 | 0.82 | LMNA (0.51) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL28763089 | 0.81 | CFTR (0.48) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL27693457 | 0.81 | MEN1 (0.46) | KDM4EPOLBLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |