Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397915 | 0.83 | ALDH1A1 (0.53) | TACR3MEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL394571 | 0.83 | POLB (0.58) | TACR3MEN1KMT2AL3MBTL1POLB | |
| SCHEMBL395743 | 0.82 | GAA (0.42) | TACR3MEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL22646 | 0.80 | POLB (0.54) | TACR3MEN1KMT2AL3MBTL1POLB | |
| Ethane SCHEMBL6100955 | 0.79 | TACR3 (0.54) | TACR3MEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL15958629 | 0.77 | MAPT (0.54) | ADORA3MAPT | |
| SCHEMBL3622482 | 0.76 | KMT2A (0.53) | MEN1KMT2AGAAPOLBMAPT | |
| SCHEMBL398408 | 0.76 | SMN1; SMN2 (0.54) | MEN1KMT2AGAAPOLBMAPT | |
| SCHEMBL395243 | 0.75 | CFTR (0.42) | TACR3MEN1KMT2AGAAPOLB | |
| SCHEMBL10061786 | 0.75 | MAPT (0.65) | MEN1KMT2APOLBMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101891680-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-29 | — | — | CN | disclosed |
| CN-101935301-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2013-10-16 | — | — | CN | disclosed |
| CN-101935301-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2011-01-05 | — | — | CN | disclosed |
| CN-101891680-A | The adjusting control agent of ATP- combination cassette transporters | VERTEX PHARMA | 2010-11-24 | — | — | CN | disclosed |
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |