Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2094188 | 0.87 | MAPT (0.39) | MAPTRAB9AMEN1HTTKMT2A | |
| SCHEMBL2093299 | 0.87 | MAPT (0.36) | MAPTRAB9AMEN1HTTKMT2A | |
| SCHEMBL24181283 | 0.85 | TRPA1 (0.50) | MAPTRAB9AMEN1HTTKMT2A | |
| SCHEMBL27841630 | 0.85 | MAPT (0.35) | MAPTRAB9AMEN1HTTKMT2A | |
| SCHEMBL2091798 | 0.85 | TSHR (0.45) | MAPTRAB9AMEN1HTTKMT2A | |
| SCHEMBL16959166 | 0.83 | CA2 (0.42) | MAPTRAB9AMEN1HTTKMT2A | |
| SCHEMBL16961273 | 0.82 | MEN1 (0.34) | MAPTRAB9AMEN1HTTKMT2A | |
| SCHEMBL16959167 | 0.82 | MAPT (0.43) | MAPTRAB9AMEN1HTTKMT2A | |
| SCHEMBL29951567 | 0.82 | CA1 (0.37) | MAPTRAB9AMEN1HTTKMT2A | |
| SCHEMBL24436839 | 0.82 | TP53 (0.53) | MAPTRAB9AMEN1KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101815707-B | oxadiazole diaryl compounds | MERCK SERONO S.A. (CH) | 2015-09-02 | — | — | CN | disclosed |
| CN-102993084-B | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA | 2015-05-20 | — | — | CN | disclosed |
| CN-104478821-A | Oxadiazole diaryl compounds | MERCK SERONO SA | 2015-04-01 | — | — | CN | disclosed |
| CN-102993084-A | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA | 2013-03-27 | — | — | CN | disclosed |
| CN-101001846-B | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA | 2012-11-07 | — | — | CN | disclosed |
| CN-101815707-A | oxadiazole diaryl compounds | MERCK SERONO SA | 2010-08-25 | — | — | CN | disclosed |
| CN-101001846-A | Novel alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA (CH) | 2007-07-18 | — | — | CN | disclosed |