Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.59 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23053008 | 0.84 | CCR2 (0.60) | CCR2ABCB11F10GPR35NTRK1 | |
| SCHEMBL2428965 | 0.81 | MEN1 (0.46) | CCR2ABCB11F10 | |
| SCHEMBL1553069 | 0.80 | GPR35 (0.67) | CCR2ABCB11F10GPR35 | |
| SCHEMBL2768671 | 0.79 | HRH3 (0.64) | CCR2ABCB11 | |
| SCHEMBL2767848 | 0.78 | HRH3 (0.62) | CCR2ABCB11PPARG | |
| SCHEMBL12327790 | 0.77 | GAA (0.59) | CCR2ABCB11PPARG | |
| SCHEMBL2002926 | 0.77 | CCR2 (0.74) | CCR2ABCB11F10GPR35 | |
| SCHEMBL2003911 | 0.76 | CCR2 (0.65) | CCR2ABCB11F10GPR35 | |
| SCHEMBL2005378 | 0.76 | CCR2 (0.73) | CCR2ABCB11F10GPR35 | |
| SCHEMBL6599972 | 0.76 | PPARG (0.68) | CCR2ABCB11F10GPR35PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960383-B1 | 5-SUBSTITUTED INDOLE-2-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-04-28 | — | — | EP | disclosed |
| EP-1960383-A1 | 5-SUBSTITUTED INDOLE-2-CARBOXAMIDE DERIVATIVES | F. Hoffmann-la Roche AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| US-7388095-B2 | 5-substituted indole-2-carboxamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-06-17 | — | — | US | disclosed |
| WO-2007063000-A1 | 5-SUBSTITUTED INDOLE-2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
| US-20070123525-A1 | 5-Substituted indole-2-carboxamide derivatives | HOFFMANN-LA ROCHE INC. | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123525-A1 | 5-Substituted indole-2-carboxamide derivatives | HRH4, HRH3, HCAR2 | CCR2 488/4885ABCB11 1009/4885F10 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.