Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 4/20 | 0.42 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28788213 | 0.88 | CHEK1 (0.47) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL1564849 | 0.84 | CNR1 (0.57) | MAPTKDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL5554830 | 0.81 | MAPT (0.54) | MAPTKDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL27677393 | 0.79 | CHEK1 (0.54) | MAPTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL27677400 | 0.79 | CHEK1 (0.54) | MAPTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL31532571 | 0.75 | USP30 (0.53) | CNR1CNR2 | |
| SCHEMBL31532568 | 0.75 | USP30 (0.53) | CNR1CNR2 | |
| SCHEMBL27819440 | 0.74 | DRD4 (0.42) | KDM4ERAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL31532672 | 0.74 | USP30 (0.56) | CNR1CNR2 | |
| SCHEMBL1564850 | 0.73 | MAPT (0.49) | MAPTKDM4ERAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100584840-C | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB | 2010-01-27 | — | — | CN | disclosed |
| CN-1922172-A | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB (SE) | 2007-02-28 | — | — | CN | disclosed |