Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27677400 | 1.00 | CHEK1 (0.54) | CHEK1ALOX15USP30GAAMAPT | |
| SCHEMBL1563670 | 0.84 | USP30 (0.68) | CHEK1ALOX15USP30GAAMAPT | |
| SCHEMBL1564584 | 0.81 | USP30 (0.64) | CHEK1ALOX15USP30GAAMAPT | |
| SCHEMBL28788213 | 0.81 | CHEK1 (0.47) | CHEK1USP30MAPTMEN1ALDH1A1 | |
| SCHEMBL5550850 | 0.81 | CHEK1 (0.59) | CHEK1ALOX15USP30GAAMAPT | |
| SCHEMBL27677399 | 0.79 | MAPT (0.47) | CHEK1GAAMAPTGFERMEN1 | |
| SCHEMBL5554697 | 0.78 | CHEK1 (0.56) | CHEK1ALOX15GAAMAPTGFER | |
| SCHEMBL27819440 | 0.76 | DRD4 (0.42) | MEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL1563673 | 0.73 | GAA (0.48) | CHEK1ALOX15GAAMAPTGFER | |
| SCHEMBL27657374 | 0.73 | CHEK1 (0.71) | CHEK1USP30CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100584840-C | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB | 2010-01-27 | — | — | CN | disclosed |
| CN-1922172-A | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB (SE) | 2007-02-28 | — | — | CN | disclosed |