Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | ESRRG | P62508 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6477476 | 0.91 | KDM4E (0.58) | IKBKBKDM4ENPC1MAPTRAB9A | |
| SCHEMBL27141132 | 0.85 | RAB9A (0.54) | IKBKBKDM4ENPC1MAPTRAB9A | |
| SCHEMBL497984 | 0.85 | ESRRG (0.56) | KDM4ENPC1MAPTRAB9AESRRG | |
| SCHEMBL12348717 | 0.85 | HSD17B1 (0.56) | KDM4ENPC1MAPTRAB9AESRRG | |
| SCHEMBL7259715 | 0.83 | APP (0.53) | IKBKBKDM4ENPC1MAPTRAB9A | |
| SCHEMBL2491378 | 0.83 | RAB9A (0.72) | KDM4ENPC1MAPTRAB9AESRRG | |
| SCHEMBL6805238 | 0.83 | KDM4E (0.67) | IKBKBKDM4ENPC1MAPTRAB9A | |
| SCHEMBL2550687 | 0.83 | KDM4E (0.72) | KDM4ENPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL71536 | 0.83 | RAB9A (0.66) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1144728 | 0.83 | IKBKB (0.58) | IKBKBNPC1MAPTRAB9AESRRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100584840-C | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB | 2010-01-27 | — | — | CN | disclosed |
| CN-1922172-A | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB (SE) | 2007-02-28 | — | — | CN | disclosed |