Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 2/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.31 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.31 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306662 | 0.73 | HSP90AA1 (0.39) | PIK3CDABL1EGFRKDRPIK3CA | |
| SCHEMBL24884485 | 0.71 | KMT2A (0.34) | MAPTCYP4F2CYP4A11 | |
| SCHEMBL16428212 | 0.69 | CYP4F2 (0.39) | MAPTCYP4F2CYP4A11 | |
| SCHEMBL1862485 | 0.69 | LMNA (0.36) | MAPTPIK3CDABL1EGFRKDR | |
| SCHEMBL27677778 | 0.68 | ALDH1A1 (0.33) | — | |
| SCHEMBL400899 | 0.67 | ALDH1A1 (0.33) | ABL1SRC | |
| SCHEMBL20306392 | 0.67 | CYP4F2 (0.43) | MAPTCYP4F2CYP4A11 | |
| SCHEMBL21825918 | 0.67 | MAP4K1 (0.33) | CYP4F2CYP4A11 | |
| SCHEMBL1860579 | 0.67 | ALDH1A1 (0.40) | HSP90AA1HSP90AB1 | |
| SCHEMBL22290799 | 0.66 | CYP4F2 (0.39) | MAPTCYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101023079-B | Substituted hydantoins for the treatment of cancer | HOFFMANN LA ROCHE | 2010-05-05 | — | — | CN | disclosed |
| CN-101023079-A | Substituted hydantoins for the treatment of cancer | HOFFMANN LA ROCHE (CH) | 2007-08-22 | — | — | CN | disclosed |