Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4113751 | 1.00 | KMT2A (0.45) | KMT2AMEN1SMYD3POLBPRCP | |
| Hydrochloric Acid SCHEMBL27646595 | 0.98 | KMT2A (0.47) | KMT2AMEN1SMYD3POLBPRCP | |
| Hydrochloric Acid SCHEMBL1509727 | 0.98 | KMT2A (0.47) | KMT2AMEN1SMYD3POLBPRCP | |
| Hydrochloric Acid SCHEMBL31263635 | 0.78 | KMT2A (0.43) | KMT2AMEN1SMYD3POLBPRCP | |
| SCHEMBL29350565 | 0.78 | GAA (0.58) | KMT2AMEN1PRCPOPRM1OPRD1 | |
| SCHEMBL29350888 | 0.78 | GAA (0.58) | KMT2AMEN1PRCPOPRM1OPRD1 | |
| SCHEMBL43168 | 0.78 | GAA (0.58) | KMT2AMEN1PRCPOPRM1OPRD1 | |
| SCHEMBL29398238 | 0.78 | GAA (0.58) | KMT2AMEN1PRCPOPRM1OPRD1 | |
| SCHEMBL288272 | 0.78 | GAA (0.58) | KMT2AMEN1PRCPOPRM1OPRD1 | |
| SCHEMBL288260 | 0.78 | GAA (0.58) | KMT2AMEN1PRCPOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675578-B9 | INHIBITORS OF GLUTAMINYL AND GLUTAMATE CYCLASES FOR THE TREATMENT OF THE NEURODEGENERATIVE DISEASES FBD AND FDD | PROBIODRUG AG (DE) | 2014-06-25 | — | — | EP | claimed |
| EP-1675578-B1 | INHIBITORS OF GLUTAMINYL AND GLUTAMATE CYCLASES FOR THE TREATMENT OF THE NEURODEGENERATIVE DISEASES FBD AND FDD | PROBIODRUG AG (DE) | 2013-05-22 | — | — | EP | claimed |
| EP-1620082-B9 | MEDICAL USE OF INHIBITORS OF GLUTAMINYL AND GLUTAMATE CYCLASES FOR TREATING ALZHEIMER'S DISEASE AND DOWN SYNDROME | PROBIODRUG AG (DE) | 2010-08-25 | — | — | EP | claimed |
| EP-1620082-B1 | MEDICAL USE OF INHIBITORS OF GLUTAMINYL AND GLUTAMATE CYCLASES FOR TREATING ALZHEIMER'S DISEASE AND DOWN SYNDROME | PROBIODRUG AG (DE) | 2010-04-21 | — | — | EP | claimed |