Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 4/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190015 | 0.89 | MAP2K1 (0.52) | MAP2K1MTNR1AKMT2AAXLGRM8 | |
| SCHEMBL27750328 | 0.88 | MAP2K1 (0.51) | MAP2K1MTNR1AKMT2AAXLGRM8 | |
| SCHEMBL30713630 | 0.88 | MAP2K1 (0.51) | MAP2K1MTNR1AKMT2AAXLGRM8 | |
| SCHEMBL4201283 | 0.87 | MAP2K1 (0.57) | MAP2K1MTNR1AKMT2AAXLGRM8 | |
| SCHEMBL12491066 | 0.82 | AXL (0.51) | MAP2K1MTNR1AKMT2AAXLGRM8 | |
| SCHEMBL30068926 | 0.82 | AXL (0.55) | MAP2K1MTNR1AKMT2AAXLGRM8 | |
| SCHEMBL820352 | 0.82 | AXL (0.55) | MAP2K1MTNR1AKMT2AAXLGRM8 | |
| SCHEMBL14828716 | 0.80 | MAP2K1 (0.52) | MAP2K1MTNR1AKMT2AAXLGRM8 | |
| SCHEMBL15142332 | 0.80 | GRM8 (0.49) | MAP2K1MTNR1AKMT2AAXLGRM8 | |
| SCHEMBL22430456 | 0.79 | AXL (0.51) | MAP2K1MTNR1AKMT2AAXLGRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103402996-B | Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD) | NOVARTIS AG | 2015-02-11 | — | — | CN | disclosed |
| CN-103402996-A | Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD) | NOVARTIS AG | 2013-11-20 | — | — | CN | disclosed |
| CN-101014597-A | Azaindoles useful as inhibitors of rock and other protein kinases | VERTEX PHARMA (US) | 2007-08-08 | — | — | CN | disclosed |