SCHEMBL27680973

SCHEMBL27680973

Cc1cc(C(=O)O)nc(N2CCNC(=O)C2)n1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
RBP4 P02753 17/20 0.47
TTR P02766 6/20 0.43
KDM4E B2RXH2 1/20 0.42
USP2 O75604 1/20 0.42
HPGD P15428 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
HSD17B10 Q99714 1/20 0.42
PPARG P37231 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1179851 0.77 RBP4 (0.59) RBP4TTRKDM4EUSP2HPGD
SCHEMBL5216228 0.76 RBP4 (0.57) RBP4TTRKDM4EUSP2HPGD
SCHEMBL28764749 0.75 RBP4 (0.60) RBP4TTRKDM4EUSP2HPGD
SCHEMBL3113600 0.73 KMT2A (0.60) RBP4KDM4EUSP2HPGDNPSR1
SCHEMBL27680981 0.72 KDM4E (0.60) RBP4TTRKDM4EUSP2HPGD
SCHEMBL5448462 0.72 TSHR (0.37) KDM4EHSD17B10
SCHEMBL13494044 0.71 KDM4E (0.81) RBP4TTRKDM4EUSP2HPGD
SCHEMBL31426975 0.71 RBP4 (0.56) RBP4TTRKDM4EUSP2HPGD
SCHEMBL27700154 0.71 RBP4 (0.53) RBP4TTRKDM4EUSP2HPGD
SCHEMBL16048627 0.71 POLB (0.53) RBP4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101023063-A Azine-carboxamides as anti-cancer agents ASTRAZENECA AB (SE) 2007-08-22 CN disclosed