Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bromperidol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 12/20 | 0.80 |
| ▸ | DRD3 | P35462 | 3/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.80 |
| ▸ | HTR1A | P08908 | 2/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.80 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.80 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.80 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.80 |
| ▸ | HTR2A | P28223 | 2/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.80 |
| ▸ | HRH1 | P35367 | 2/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.80 |
| ▸ | HTR2B | P41595 | 2/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Haloperidol SCHEMBL19463557 | 0.91 | DRD2 (0.80) | DRD2DRD3CYP1A2CYP3A4HTR1A | |
| Haloperidol SCHEMBL4177109 | 0.91 | DRD2 (0.80) | DRD2DRD3CYP1A2CYP3A4HTR1A | |
| Haloperidol SCHEMBL41057 | 0.91 | DRD2 (0.80) | DRD2DRD3CYP1A2CYP3A4HTR1A | |
| Haloperidol SCHEMBL28595609 | 0.90 | DRD2 (0.78) | DRD2DRD3CYP1A2CYP3A4HTR1A | |
| Bromperidol SCHEMBL43755 | 0.89 | DRD2 (1.00) | DRD2DRD3CYP1A2CYP3A4HTR1A | |
| SCHEMBL20653047 | 0.89 | DRD2 (1.00) | DRD2DRD3CYP1A2CYP3A4HTR1A | |
| Haloperidol SCHEMBL10392879 | 0.86 | DRD2 (0.72) | DRD2DRD3CYP1A2CYP3A4HTR1A | |
| Haloperidol SCHEMBL10392880 | 0.86 | DRD2 (0.72) | DRD2DRD3CYP1A2CYP3A4HTR1A | |
| Haloperidol SCHEMBL5452448 | 0.86 | DRD2 (0.72) | DRD2DRD3CYP1A2CYP3A4HTR1A | |
| Bromperidol SCHEMBL28339258 | 0.85 | DRD2 (0.88) | DRD2DRD3CYP1A2CYP3A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109462995-A | The method and composition of bioactivator | 波涛生命科学有限公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-1964713-A | Co-use of dopamine-receptor binding compounds | DARPHARMA INC (US) | 2007-05-16 | — | — | CN | disclosed |