Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Haloperidol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 15/20 | 0.72 |
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.72 |
| ▸ | DRD4 known ✓ | P21917 | 3/20 | 0.72 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.72 |
| ▸ | HTR1A | P08908 | 3/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.72 |
| ▸ | HRH1 | P35367 | 3/20 | 0.72 |
| ▸ | HTR2C | P28335 | 2/20 | 0.72 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.72 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Haloperidol SCHEMBL19463557 | 0.95 | DRD2 (0.80) | DRD2DRD3ADRA1ADRD4HTR1A | |
| Haloperidol SCHEMBL4177109 | 0.95 | DRD2 (0.80) | DRD2DRD3ADRA1ADRD4HTR1A | |
| Haloperidol SCHEMBL41057 | 0.95 | DRD2 (0.80) | DRD2DRD3ADRA1ADRD4HTR1A | |
| Haloperidol SCHEMBL28595609 | 0.94 | DRD2 (0.78) | DRD2DRD3ADRA1ADRD4HTR1A | |
| Haloperidol SCHEMBL42239 | 0.92 | DRD2 (0.84) | DRD2DRD3ADRA1ADRD4HTR1A | |
| Haloperidol SCHEMBL10392880 | 0.90 | DRD2 (0.72) | DRD2DRD3ADRA1ADRD4HTR1A | |
| Haloperidol SCHEMBL10392879 | 0.90 | DRD2 (0.72) | DRD2DRD3ADRA1ADRD4HTR1A | |
| Haloperidol Decanoate SCHEMBL8510008 | 0.90 | DRD2 (0.82) | DRD2DRD3ADRA1ADRD4HTR1A | |
| Bromperidol SCHEMBL27681710 | 0.86 | DRD2 (0.80) | DRD2DRD3ADRA1ADRD4HTR1A | |
| Trifluperidol SCHEMBL4122414 | 0.85 | ABCB11 (0.73) | DRD2DRD3ADRA1ADRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070142411-A1 | Use of cyclooxygenase-2 selective inhibitors for the treatment of schizophrenic disorders | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142411-A1 | Use of cyclooxygenase-2 selective inhibitors for the treatment of schizophrenic disorders | PTGES2, PTGER2, PTGDR2 | DRD2 120/4885DRD3 304/4885DRD4 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.