Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954163 | 0.97 | SLC6A2 (0.47) | ADAM17METAP2SLC6A2SLC6A4 | |
| SCHEMBL3960434 | 0.86 | MEN1 (0.46) | HTTLMNAMEN1MAPTKMT2A | |
| SCHEMBL3961259 | 0.86 | KMT2A (0.41) | MEN1MAPTKMT2ASCN5ASCN9A | |
| SCHEMBL3955844 | 0.84 | SLC6A2 (0.43) | SLC6A2SLC6A4HPGD | |
| SCHEMBL3951075 | 0.84 | CYP2C9 (0.44) | METAP2HTTMAPTSLC6A2SLC6A4 | |
| SCHEMBL3956055 | 0.83 | CYP3A4 (0.43) | METAP2HTTLMNAMAPTSLC6A2 | |
| SCHEMBL3952525 | 0.83 | LMNA (0.45) | HTTLMNAMEN1KMT2ASLC6A2 | |
| SCHEMBL3955939 | 0.83 | CYP2C9 (0.42) | LMNAMEN1KMT2ASCN5ASCN9A | |
| SCHEMBL3955379 | 0.82 | ALDH1A1 (0.43) | METAP2LMNAMEN1MAPTKMT2A | |
| SCHEMBL3980389 | 0.80 | SLC6A2 (0.49) | MEN1KMT2ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1972920-A | Arylalkyl piperazine derivatives for the treatment of conditions ameliorated by monoamine reuptake including vasomotor symptoms | WYETH CORP (US) | 2007-05-30 | — | — | CN | disclosed |