Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28826276 | 0.88 | ALOX5 (0.41) | ALDH1A1NPC1MAPTMAPK1HTT | |
| SCHEMBL6762993 | 0.82 | AAK1 (0.41) | ALDH1A1NPC1MAPTMAPK1HTT | |
| SCHEMBL17254362 | 0.79 | ALOX5 (0.49) | ALDH1A1NPC1MAPTRAB9AALOX5 | |
| SCHEMBL17241438 | 0.79 | ALOX5 (0.49) | ALDH1A1NPC1MAPTRAB9AALOX5 | |
| SCHEMBL17241382 | 0.78 | MAPT (0.38) | NPC1MAPTRAB9AL3MBTL1 | |
| SCHEMBL5780065 | 0.77 | TYR (0.44) | ALDH1A1NPC1MAPTRAB9AADRB2 | |
| SCHEMBL2953235 | 0.77 | PTGS2 (0.47) | ALOX5 | |
| SCHEMBL17254313 | 0.75 | ALOX5 (0.33) | ALOX5 | |
| SCHEMBL186630 | 0.72 | ALOX5 (0.42) | ALDH1A1L3MBTL1ALOX5 | |
| SCHEMBL3897727 | 0.72 | ALOX5 (0.42) | ALDH1A1L3MBTL1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100338036-C | Substituted indolinones with inhibitory effect on kinase and cyclin complexes | BOEHRINGER INGELHEIM PHARMA (DE) | 2007-09-19 | — | — | CN | disclosed |