Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A known ✓ | P11388 | 2/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.70 |
| ▸ | CFTR | P13569 | 1/20 | 0.50 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.44 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27684270 | 0.85 | MGAM (0.50) | MGAMCFTRSLC13A5RAB9ATOP2A | |
| SCHEMBL29362407 | 0.84 | MGAM (1.00) | MGAMCFTRRAB9ATOP2ATOP2B | |
| SCHEMBL28048 | 0.84 | MGAM (1.00) | MGAMCFTRRAB9ATOP2ATOP2B | |
| Citric Acid SCHEMBL28264671 | 0.84 | MGAM (0.47) | MGAMCFTRSLC13A5RAB9AKDR | |
| Water SCHEMBL28182355 | 0.82 | MGAM (0.96) | MGAMCFTRRAB9ATOP2ATOP2B | |
| Hydrochloric Acid SCHEMBL9114407 | 0.82 | MGAM (0.96) | MGAMCFTRRAB9ATOP2ATOP2B | |
| SCHEMBL27565246 | 0.82 | MGAM (0.96) | MGAMCFTRRAB9ATOP2ATOP2B | |
| Hydrochloric Acid SCHEMBL1649216 | 0.82 | MGAM (0.96) | MGAMCFTRRAB9ATOP2ATOP2B | |
| Fluoride SCHEMBL27513846 | 0.82 | MGAM (0.96) | MGAMCFTRRAB9ATOP2ATOP2B | |
| Fluoride SCHEMBL27790822 | 0.82 | MGAM (0.96) | MGAMCFTRRAB9ATOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100386081-C | Injection containing tricyclofluoro quinolone sulfonate and its preparing method and use | CHONGQING BIOLOG PRODUCT CO LT (CN) | 2008-05-07 | — | — | CN | disclosed |
| CN-1985826-A | Injection containing tricyclofluoro quinolone sulfonate and its preparing method and use | CHONGQING BIOLOG PRODUCT CO LT (CN) | 2007-06-27 | — | — | CN | disclosed |