Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL27684271 | 0.84 | MGAM (0.70) | MGAMSLC13A5RAB9ACFTRKDR | |
| Trifluoroacetic Acid SCHEMBL30684640 | 0.81 | MGAM (0.53) | MGAMRAB9ACFTRKDRALDH1A1 | |
| Acetic Acid SCHEMBL7836636 | 0.79 | MGAM (0.57) | MGAMRAB9ACFTRKDRALDH1A1 | |
| Citric Acid SCHEMBL5874845 | 0.79 | ALDH1A1 (0.53) | SLC13A5ALDH1A1KDM4EKMT2ALMNA | |
| Citric Acid SCHEMBL5874858 | 0.79 | ALDH1A1 (0.53) | SLC13A5ALDH1A1KDM4EKMT2ALMNA | |
| SCHEMBL27684270 | 0.78 | MGAM (0.50) | MGAMSLC13A5RAB9ACFTRKDR | |
| SCHEMBL14678 | 0.77 | CYP1A2 (0.57) | MGAMRAB9AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL29418017 | 0.77 | CYP1A2 (0.57) | MGAMRAB9AALDH1A1KDM4ECYP1A2 | |
| Citric Acid SCHEMBL28296321 | 0.76 | ALDH1A1 (0.50) | SLC13A5ALDH1A1KDM4EKMT2ALMNA | |
| Citric Acid SCHEMBL21145048 | 0.76 | ALDH1A1 (0.60) | SLC13A5ALDH1A1KDM4EKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106977512-B | The method for preparing the smooth free alkali of horse sieve | 海门慧聚药业有限公司 | 2019-01-01 | — | — | CN | disclosed |