Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HPRT1 | P00492 | 3/20 | 0.44 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | AHR | P35869 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27725822 | 0.80 | HPRT1 (0.54) | MAPTL3MBTL1TSHRCYP3A4MAPK1 | |
| SCHEMBL15635420 | 0.75 | HPRT1 (0.52) | MAPTL3MBTL1TSHRCYP3A4MAPK1 | |
| SCHEMBL28105537 | 0.74 | HPRT1 (0.47) | MAPTCYP3A4MAPK1HSD17B10HPRT1 | |
| SCHEMBL27444109 | 0.73 | HPRT1 (0.50) | MAPTTSHRCYP3A4MAPK1HPGD | |
| SCHEMBL27594916 | 0.73 | HPRT1 (0.50) | MAPTTSHRCYP3A4MAPK1HPGD | |
| SCHEMBL15910811 | 0.73 | HSD17B10 (0.50) | MAPTL3MBTL1TSHRCYP3A4MAPK1 | |
| SCHEMBL27278968 | 0.72 | CYP1A2 (0.48) | MAPTTSHRCYP3A4MAPK1HPGD | |
| SCHEMBL2837198 | 0.72 | HSD17B10 (0.64) | MAPTL3MBTL1TSHRCYP3A4MAPK1 | |
| SCHEMBL17841964 | 0.72 | HPRT1 (0.58) | MAPTL3MBTL1TSHRCYP3A4MAPK1 | |
| SCHEMBL27760500 | 0.72 | TRPM4 (0.65) | MAPTTSHRHPGDHSD17B10HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101023074-B | Inhibitors of the interaction between MDM2 and P53 | JANSSEN PHARMACEUTICA NV | 2012-10-10 | — | — | CN | disclosed |
| CN-101023074-A | Inhibitors of the interaction between MDM2 and P53 | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-22 | — | — | CN | disclosed |