Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 11/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27686241 | 0.93 | ROCK1 (0.39) | GRM2CYSLTR1PTGER1CYP2C9CYP3A4 | |
| SCHEMBL481464 | 0.86 | CYSLTR1 (0.49) | GRM2CYSLTR1PTGER1CYP2C9MAPT | |
| SCHEMBL5200639 | 0.81 | PTGER1 (0.34) | GRM2CYSLTR1PTGER1CYP2C9CYP3A4 | |
| SCHEMBL481191 | 0.79 | GRM2 (0.47) | GRM2CYSLTR1CYP2C9MAPTKMT2A | |
| SCHEMBL5275712 | 0.74 | MEN1 (0.38) | GRM2CYSLTR1PTGER1KMOKDM4E | |
| SCHEMBL27686389 | 0.73 | SLC26A3 (0.47) | GRM2MRGPRX4 | |
| SCHEMBL27711668 | 0.73 | PDK2 (0.37) | CYP2C9RXRAMRGPRX4KDM4EALDH1A1 | |
| SCHEMBL27686251 | 0.73 | APP (0.43) | RXRAMRGPRX4KDM4EALDH1A1HPGD | |
| SCHEMBL27686308 | 0.71 | PDK2 (0.36) | CYP2C9RXRAMRGPRX4KDM4EALDH1A1 | |
| SCHEMBL28769414 | 0.70 | CYSLTR1 (0.49) | GRM2CYSLTR1MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101955470-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-06-13 | — | — | CN | disclosed |
| CN-101955470-A | Glutamate receptor potentiators | LILLY CO ELI | 2011-01-26 | — | — | CN | disclosed |
| CN-101061106-B | Glutamate receptor potentiators | LILLY CO ELI | 2010-09-29 | — | — | CN | disclosed |
| CN-101061106-A | Glutamate receptor potentiators | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |