Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 14/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5275712 | 0.93 | MEN1 (0.38) | PTGER1GRM2CYSLTR1 | |
| SCHEMBL481464 | 0.84 | CYSLTR1 (0.49) | PTGER1GRM2CYSLTR1CYP2C9 | |
| SCHEMBL27686232 | 0.81 | GRM2 (0.36) | PTGER1GRM2CYSLTR1CYP2C9CYP3A4 | |
| SCHEMBL481191 | 0.77 | GRM2 (0.47) | GRM2CYSLTR1CYP2C9 | |
| SCHEMBL27686241 | 0.74 | ROCK1 (0.39) | PTGER1GRM2CYSLTR1CYP2C9CYP3A4 | |
| SCHEMBL5200479 | 0.72 | SLC26A3 (0.44) | MRGPRX4 | |
| SCHEMBL5200321 | 0.71 | APP (0.44) | MRGPRX4 | |
| SCHEMBL5199078 | 0.71 | CCR5 (0.36) | MRGPRX4 | |
| SCHEMBL5750187 | 0.67 | KMO (0.43) | — | |
| SCHEMBL1755755 | 0.65 | CYSLTR1 (0.44) | GRM2CYSLTR1CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817301-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057870-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |